HotSpot Therapeutics is inspired by nature and leading a paradigm shift in drug discovery by unlocking the on/off switches on proteins called “natural hotspots” to enable differentiated medicines for patients. HotSpot has moved beyond active site inhibition and created a groundbreaking new discovery paradigm. By allosterically targeting protein pockets that drive protein function, we can reprogram control mechanisms to deliver first- and/or best-in-class medicines